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Limulus Amebocyte Lysate (LAL)

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By: Tim Wright

Editor-in-Chief, Contract Pharma

The standard in-vitro assay used to test for endotoxin presence, much preferred over the in-vivo rabbit pyrogen test. LAL is an aqueous extract of blood cells (amoebocytes) from the horseshoe crab, Limulus polyphemus. LAL reacts with bacterial endotoxin or lipopolysaccharide (LPS), which is a membrane component of Gram negative bacteria. This reaction is the basis of the LAL test, which is used for the detection and quantification of bacterial endotoxins.

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